Homotherapy for heteropathy: therapeutic effect of Butein in NLRP3-driven diseases
Abstract Background Aberrant inflammatory responses drive the initiation and progression of various diseases, and hyperactivation of NLRP3 inflammasome is a key pathogenetic mechanism.Pharmacological inhibitors of NLRP3 represent a potential therapy for treating these diseases but are not yet clinically available.The natural product butein has exce